click into different sections:


  • 2006 Discovery [1]

  • 2021 Secondary-structure motif [2]


The LongInterspersed Nuclear Element-1 (LINE-1) ribozyme is a nucleolytic ribozyme located in the 5' untranslated region of a LINE-1 retrotransposon.


[1] A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene.
Salehi-Ashtiani, K., Luptak, A., Litovchick, A. and Szostak, J.W.
Science 313 (5794): 1788-92.(2006)

[2] Resurrecting self-cleaving mini-ribozymes from 40-million-year-old LINE-1 elements in human genome.
Zhang, Z., Xiong, P., Wang, J., Zhan, J. and Zhou, Y.
BioRxiv preprint.(2021)